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Engaging a Certified Diabetes Care and Education Specialist (CDCES) in the treatment team can further improve long term outcomes and adherence to treatment (122)

According to the current paradigm, glutamate-driven excitotoxicity, activation of calcium-dependent proteases, over activation of calcium-regulated kinases and phosphatases, and mitochondrial calcium overload resulting in mPTP opening (53, 54) are some of the mechanisms by which generalized calcium overload in neurons causes neuronal death (54, 55)